Within Teamwork Desk, you can enable Teamwork CRM for your site.

Click your profile icon in the top right of your site and select Settings from the dropdown menu.

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Note: Only site administrators can access the Apps settings and enable integrations.

In the Settings area, go to the Apps tab where you will see an option for Teamwork CRM.

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Click Enable to turn Teamwork CRM on for your site. 

It is also possible to enable Teamwork CRM through your product switcher

For more information, see: Working with Teamwork CRM