Within each Teamwork product, you can enable Teamwork CRM for your site through the site settings. 

Teamwork

In Teamwork, select the Integrations tab in your site settings and scroll to the Teamwork CRM option. Click the trial button to enable it for your site.

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It is also possible to enable Teamwork CRM through your Teamwork product switcher

Teamwork Desk

In Teamwork Desk, go to the Apps section of your site settings.

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Here, you will see an option for Teamwork CRM. Click Enable to enable it for your site.

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Similarly to Teamwork, you can enable Teamwork CRM through your Teamwork Desk product switcher

For more information, see: Understanding Key Terms in Teamwork CRM